Clinical epidemiology of acute hepatitis C in South America

Authors
Dirchwolf, Melisa; Marciano, Sebastián; Mauro, Ezequiel; Ruf, Andrés Eduardo; Rezzonico, Lucrecia; Anders, Margarita; Chiodi, Daniela; Gill Petta, Néstor; Borzi, Silvia; Tanno, Federico; Ridruejo, Ezequiel; Barreyro, Fernando Javier; Shulman, Carolina; Plaza, Pablo Maximiliano; Carbonetti, Rodolfo; Tadey, Luciana; Schroder, Teresa; Fainboim, Hugo
Publication Year
2017
Language
English
Format
article
Status
Published version
Description
There is scarce data pertaining to acute hepatitis C (aHC) infection in South America. We aimed to describe clinical characteristics and evolution of aHC in a South American cohort. A retrospective survey was conducted at 13 hepatology units. All patients ≥16 years old with aHC diagnosis were included. Demographic, clinical and outcome information were registered in a standardized ad hoc questionnaire. Sixty-four patients were included. The majority were middle-aged (median age: 46 years) and female (65.6%); most of them were symptomatic at diagnosis (79.6%). HCV-1 was the most prevalent genotype (69.2%). Five patients had liver failure: three cases of severe acute hepatitis, one case of fulminant hepatitis and one case of acute-on-chronic liver failure. Nosocomial exposure was the most prevalent risk factor. Evolution was assessed in 46 patients. In the untreated cohort, spontaneous resolution occurred in 45.8% and was associated with higher values of AST/ALT and with the absence of intermittent HCV RNA viremia (P = 0.01, 0.05, and 0.01, respectively). In the treated cohort, sustained virological response was associated with nosocomial transmission and early treatment initiation (P = 0.04 each). The prevalence of nosocomial transmission in this South-American cohort of aHC stresses the importance of following universal precautions to prevent HCV infection
Fil: Dirchwolf, Melisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Marciano, Sebastián. Hospital Italiano; Argentina
Fil: Mauro, Ezequiel. Hospital Italiano; Argentina
Fil: Ruf, Andrés Eduardo. Fundación para la Docencia e Investigación de las Enfermedades del Hígado; Argentina
Fil: Rezzonico, Lucrecia. Hospital de la Asociación Médica “Dr. Felipe Glasman”; Argentina
Fil: Anders, Margarita. Hospital Alemán; Argentina
Fil: Chiodi, Daniela. Universidad de la República; Uruguay
Fil: Gill Petta, Néstor. Hospital Central del Instituto de Previsión Social; Paraguay
Fil: Borzi, Silvia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos Prof. Dr. Rodolfo Rossi; Argentina
Fil: Tanno, Federico. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas ; Argentina
Fil: Barreyro, Fernando Javier. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Fil: Shulman, Carolina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos Dr. Enrique Tornú; Argentina
Fil: Plaza, Pablo Maximiliano. Provincia de Salta. Ministerio de Salud Pública. Hospital Señor del Milagro; Argentina
Fil: Carbonetti, Rodolfo. Provincia de Tucumán. Ministerio de Salud. Hospital de Clínicas Presidente Dr. Nicolás Avellaneda; Argentina
Fil: Tadey, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Schroder, Teresa. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Fainboim, Hugo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Subject
HEPATITIS C
ACUTE HEPATITIS
EPIDEMIOLOGY
NOSOCOMIAL TRANSMISSION
LATIN AMERICA
Medicina Critica y de Emergencia
Medicina Clínica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/41492