Influence of yogurt consumption on the respiratory immune response

Authors
Racedo, Silvia María; Villena, Julio Cesar; Salva, Maria Susana; Alvarez, Gladis Susana
Publication Year
2009
Language
English
Format
article
Status
Published version
Description
The influence of two yogurts, made with different starter strains, on the immune response against a respiratory pathogen was studied. Yogurt P (YP) was prepared with the immune-enhancing strains Lactobacillus bulgaricus CRL 423 and Streptococcus thermophilus CRL 412. Control yogurt (YC) was prepared with L. bulgaricus AV31 and S. thermophilus AV4 strains with no intrinsic immunoenhancing activity. Swiss albino mice were fed YP or YC for five days and infected intranasally with Streptococcus pneumoniae on day 6. The resistance to the infection and innate and specific immune responses were studied. Results showed that both yogurts were able to improve the resistance against pneumococcal infection when compared with control mice. However, YP was more effective than YC in protecting the mice against the infection. Both yogurts improved the activation and recruitment of phagocytes in the respiratory tract, but only YP was capable of increasing the number of IgA cells in the bronchus and the levels of pathogen specific IgA and IgG in the airways and serum. Our results show that the consumption of yogurt is able to enhance immunity in the respiratory tract. In addition, we demonstrate that the protective effect of yogurt could be improved if it is prepared with starter strains of L. bulgaricus and S. thermophils that have intrinsic immunomodulatory activity.
Fil: Racedo, Silvia María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Subject
PROBIOTIC
RESPIRATORY INFECTION
STREPTOCOCCUS PNEUMONIAE
YOGURT
Otras Ciencias Biológicas
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/56022