Effects of maternal stress during different periods of pregnancy on the early neurobehavioral response of rats

Authors
Kvarik, Timea; Mammel, Barbara; Reglodi, Dora; Antonelli, Marta Cristina; Farkas, Jozsef; Tamas, Andrea; Ertl, Tibor; Atlasz, Tamas; Bodzai, Greta; Kiss, Peter; Gyarmati, Judit
Publication Year
2016
Language
English
Format
article
Status
Published version
Description
Background: Several studies focus on the effects of prenatal stress in adulthood. Relatively little is known about the early neurodevelopmental consequences of such experiences and their predictive value. Thus we examined the early neurobehavioral responses of offspring whose mothers were exposed to restraint stress. Methods and results: Pregnant rats were exposed to 60 minutes restraint stress twice a day for seven days in different periods of pregnancy (early/mid and late phase). After birth, offspring were examined for the maturation of neural signs and reflexes daily for 3 weeks. Mid-pregnancy stress resulted in a subtle faster development in the appearance of eyelid and auditory startle reflexes, and in the disappearance of crossed extensor reflex. Pups exposed to stress in the last week of intrauterine life displayed a delay in air righting and showed a slight enhancement in the appearance of auditory startle. Conclusion: Based on our present findings, the deleterious consequences of prenatal stress are not apparent during the early developmental stages at least not detectable with the battery of test most widely used to examine neurobehavioral development. However, these findings draw the attention of the need of careful awareness in later ages in spite of the normal neurobehavioral development of newborns exposed to prenatal stress.
Fil: Kvarik, Timea. University of Pécs; Hungría
Fil: Mammel, Barbara. University of Pécs; Hungría
Fil: Reglodi, Dora. University of Pécs; Hungría
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Farkas, Jozsef. University of Pécs; Hungría
Fil: Tamas, Andrea. University of Pécs; Hungría
Fil: Ertl, Tibor. University of Pécs; Hungría
Fil: Atlasz, Tamas. University of Pécs; Hungría
Fil: Bodzai, Greta. University of Pécs; Hungría
Fil: Kiss, Peter. University of Pécs; Hungría
Fil: Gyarmati, Judit. University of Pécs; Hungría
Subject
RESTRAINT STRESS PRENATAL
MATERNAL
NEROBEHAVIORAL
DEVELOPMENT
RAT
Neurociencias
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Open access
License
https://creativecommons.org/licenses/by/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/17824