PIB: A score to select sorafenib treatment candidates for hepatocellular carcinoma in resource-limited settings

Authors
Leathers, James S.; Balderramo, Domingo; Prieto, Jhon; Diehl, Fernando; Gonzalez-Ballerga, Esteban; Ferreiro, Melina R.; Carrera, Enrique; Barreyro, Fernando Javier; Diaz Ferrer, Javier; Singh, Dupinder; Mattos, Angelo Z.; Carrilho, Flair; Debes, Jose D.
Publication Year
2018
Language
English
Format
article
Status
Published version
Description
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death globally. Sorafenib, a multi-tyrosine kinase inhibitor, remains the standard of care for patients with inoperable or advanced-stage HCC. In resource-limited settings without access to surgical or locoregional therapy, sorafenib may be the only option for treating HCC. However, due to a modest survival benefit, as well as the limiting cost of sorafenib in certain regions, appropriate selection of patients for treatment is essential. Evaluation of Barcelona Clinic Liver Cancer (BCLC) criteria in resource-limited settings is frequently unachievable due to a variety of reasons. Using a cohort from the South American liver research network (1336 HCC cases), we created a cost-effective prognostic scoring system to help identify patients likely to have a survival benefit on sorafenib treatment, using simple laboratory variable
Fil: Leathers, James S.. Vanderbilt University; Estados Unidos
Fil: Balderramo, Domingo. Universidad de Córdoba; España
Fil: Prieto, Jhon. Centro de Enfermedades Hepáticas y Digestivas; Colombia
Fil: Diehl, Fernando. Universidad de Córdoba; España
Fil: Gonzalez-Ballerga, Esteban. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Ferreiro, Melina R.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Carrera, Enrique. Hospital Eugenio Espejo; Ecuador
Fil: Barreyro, Fernando Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Fil: Diaz Ferrer, Javier. Hospital Nacional Edgardo Rebagliati Martins; Perú
Fil: Singh, Dupinder. University of Minnesota; Estados Unidos
Fil: Mattos, Angelo Z.. Universidade Federal de Ciencias Da Saúde de Porto Alegre; Brasil
Fil: Carrilho, Flair. Universidade de Sao Paulo; Brasil
Fil: Debes, Jose D.. University of Minnesota; Estados Unidos
Subject
HCC
HEPATOCELLULAR CARCINOMA
SCORE
SORAFENIB
Gastroenterología y Hepatología
Medicina Clínica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Open access
License
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/85699