Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance

Authors
Tellechea, Mariana Lorena; Penas Steinhardt, Alberto; Rodriguez, G.; Taverna, Mariano Javier; Poskus, Edgardo; Frechtel, G.
Publication Year
2012
Language
English
Format
article
Status
Published version
Description
Background and Aims: Specific Suppressor Of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR. Methods and Results: 780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ≥ 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (P = 0.005) and abdominal obesity (P = 0.002) and allele C carriers showed, in comparison with TT-carriers, lower BMI (P = 0.001) and waist circumference (P = 0.001). rs8074124CC- carriers showed lower fasting insulin (P = 0.017) and HOMA-IR (P = 0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (P = 0.009) and hypertriglyceridemic waist (P = 0.006). rs12051836CC- carriers showed lower fasting insulin (P = 0.043) and HOMA-IR (P = 0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (P = 0.026) and HDL-C (P = 0.014) as a continuous variable. Conclusion: We found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders.
Fil: Tellechea, Mariana Lorena. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Penas Steinhardt, Alberto. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
Fil: Rodriguez, G.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Taverna, Mariano Javier. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Poskus, Edgardo. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
Fil: Frechtel, G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Subject
SOCS7
INSULIN RESISTANCE
TAGSNPs
INFLAMMATION
Genética Humana
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/8049