Endothelin-2 differential expression in normal and early-stages of colon cancer development

Authors
Bianchi, Mariana; Adur, Javier Fernando; Izaguirre, María Fernanda; Viale, Silvia; Cesar, Carlos L.; Casco, Victor Hugo
Publication Year
2013
Language
English
Format
article
Status
Published version
Description
The endothelin family has been related with several pathological diseases including cardiovascular disorders, hypertension and cancer. However, little is known about endothelin system in early stages of colorectal cancer and there are no studies evaluating differences in proximal and distal colon segments. To deepen in this issue, we have studied the endothelin’s family gene and protein expression in normal mice and early stage of a mice model of Azoxymethane (AOM) and Dextran Sodium Sulphate (DSS) induced colorectal cancer in proximal and distal segments. Additionally, using nonlinear microscopy (NLM) techniques, we have characterized collagen changes in early stages of cancer disease development. In the present study, we have found significant differential gene expression and protein localization between these colon regions, which allow us to hypothesize a new role for the ET-2 as an early marker of colon cancer development.
Fil: Bianchi, Mariana. Universidad Nacional de Entre Ríos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Adur, Javier Fernando. Universidad Nacional de Entre Ríos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Izaguirre, María Fernanda. Universidad Nacional de Entre Ríos; Argentina
Fil: Viale, Silvia. Universidad Nacional de Entre Ríos; Argentina
Fil: Cesar, Carlos L.. Universidade Estadual de Campinas; Brasil
Fil: Casco, Victor Hugo. Universidad Nacional de Entre Ríos; Argentina
Subject
Colon cancer
Endothelin-2
Azoxymethane
Dextran Sodium Sulphate
Bioquímica y Biología Molecular
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Open access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/27628