ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas

Authors
Colas, E.; Muinelo Romay, L.; Alonso Alconada, L.; Llaurado, M.; Monge, M,; Barbazan, J.; Gonzalez, M.; Schoumacher, M.; Pedrola, N.; Ertekin, T.; Devis, L.; Ruiz, A.; Castellvi, J.; Doll, A.; Gil Moreno, A,; Vazquez, Monica Hebe; Lapyckyj, Lara; Lopez Lopez, R.; Robine, S.; Friederich, E.; Castro, M.; Reventos, J.; Vignjevic, D.; Abal, M.
Publication Year
2012
Language
English
Format
article
Status
Published version
Description
Endometrial carcinoma (EC) is the most frequent among infiltrating tumors of the female genital tract, with myometrial invasion representing an increase in the rate of recurrences and a decrease in survival. We have previously described ETV5 transcription factor associated with myometrial infiltration in human ECs. In this work, we further investigated ETV5 orchestrating downstream effects to confer the tumor the invasive capabilities needed to disseminate in the early stages of EC dissemination. Molecular profiling evidenced ETV5 having a direct role on epithelial-to-mesenchymal transition (EMT). In particular, ETV5 modulated Zeb1 expression and E-Cadherin repression leading to a complete reorganization of cell-cell and cell-substrate contacts. ETV5-promoted EMT resulted in the acquisition of migratory and invasive capabilities in endometrial cell lines. Furthermore, we identified the lipoma-preferred partner protein as a regulatory partner of ETV5, acting as a sensor for extracellular signals promoting tumor invasion. All together, we propose ETV5-transcriptional regulation of the EMT process through a crosstalk with the tumor surrounding microenvironment, as a principal event initiating EC invasion.
Fil: Colas, E.. Universidad Autonoma de Barcelona. Hospital Vall D; España. Universitat Autònoma de Barcelona; España
Fil: Muinelo Romay, L.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Alonso Alconada, L.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Llaurado, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Monge, M,. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Barbazan, J.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Gonzalez, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Schoumacher, M.. Institute Curie; Francia
Fil: Pedrola, N.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Ertekin, T.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Devis, L.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Ruiz, A.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Castellvi, J.. Universidad Autónoma de Barcelona. Hospital Vall D; España
Fil: Doll, A.. Universidad Autónoma de Barcelona. Hospital Vall D; España
Fil: Gil Moreno, A,. Universidad Autonoma de Barcelona. Hospital Vall D; España. Universidad de Barcelona; España
Fil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Lapyckyj, Lara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Lopez Lopez, R.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Robine, S.. Institute Curie; Francia
Fil: Friederich, E.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Castro, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Reventos, J.. Universidad de Santiago de Compostela; España. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Vignjevic, D.. Institute Curie; Francia
Fil: Abal, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España. Complexo Hospitalario Universitario de Santiago SERGAS;; España
Subject
ETV5
ENDOMETRIAL CARCINOMA
LPP
EMT
Bioquímica y Biología Molecular
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/22664