Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons

Authors
Sterenborg, Jessica C.; Pilati, Nadia; Sheridan, Craig J.; Uchitel, Osvaldo Daniel; Forsythe, Ian D.; Barnes Davies, Margaret
Publication Year
2010
Language
English
Format
article
Status
Published version
Description
We examined membrane properties and synaptic responses of neurons in the mouse lateral superior olivary nucleus (LSO). Two clear populations were identified consistent with: principal neurons which are involved in detecting interaural intensity differences (IIDs) and efferent neurons of the lateral olivocochlear (LOC) system which project to the cochlea. Principal neurons fired a short latency action potential (AP) often followed by an AP train during maintained depolarization. They possessed sustained outward K+ currents, with little or no transient K+ current (IA) and a prominent hyperpolarization-activated non-specific cation conductance, IH. On depolarization, LOC neurons exhibited a characteristic delay to the first AP. These neurons possessed a prominent transient outward current IA, but had no IH. Both LOC and principal neurons received glutamatergic and glycinergic synaptic inputs. LOC synaptic responses decayed more slowly than those of principal neurons; the mean decay time constant of AMPA receptor-mediated EPSCs was around 1 ms in principal neurons and 4 ms in LOC neurons. Decay time constants for glycinergic IPSCs were around 5 ms in principal neurons and 10 ms in LOC neurons. We conclude that principal cells receive fast synaptic responses appropriate for integration of IID inputs, while the LOC cells possess excitatory and inhibitory receptors with much slower kinetics.
Fil: Sterenborg, Jessica C.. University of Leicester; Reino Unido
Fil: Pilati, Nadia. University of Leicester; Reino Unido
Fil: Sheridan, Craig J.. University of Leicester; Reino Unido
Fil: Uchitel, Osvaldo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Forsythe, Ian D.. University of Leicester; Reino Unido
Fil: Barnes Davies, Margaret. University of Leicester; Reino Unido
Subject
Interaural intensity differences
Lateral olivocochlear
Glutamatergic synapsis
Glycinergic synapsis
Neurociencias
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/20749