A controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study

Autores
Gimeno, Marina; Pinczowski, Pedro; Pérez, Marta; Giorello, Antonella; Martinez, Miguel Angel; Santamaría, Jesús; Arruebo, Manuel; Luján, Lluis
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
Versión publicada
Descripción
A new device for local delivery of antibiotics is presented, with potential use as a drug-eluting fixation pin for orthopedic applications. The implant consists of a stainless steel hollow tubular reservoir packed with the desired antibiotic. Release takes place through several orifices previously drilled in the reservoir wall, a process that does not compromise the mechanical properties required for the implant. Depending on the antibiotic chosen and the number of orifices, the release profile can be tailored from a rapid release of the load (ca. 20 h) to a combination of rapid initial release and slower, sustained release for a longer period of time (ca. 200 h). An excellent bactericidal action is obtained, with 4-log reductions achieved in as little as 2 h, and total bacterial eradication in 8 h using 6-pinholed implants filled with cefazolin.
Fil: Gimeno, Marina. Universidad de Zaragoza; España
Fil: Pinczowski, Pedro. Universidad de Zaragoza; España
Fil: Pérez, Marta. Universidad de Zaragoza; España
Fil: Giorello, Antonella. Universidad de Zaragoza. Instituto de Nanociencia de Aragón; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica ; Argentina
Fil: Martinez, Miguel Angel. Universidad de Zaragoza; España. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN; España
Fil: Santamaría, Jesús. Universidad de Zaragoza; España. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN; España
Fil: Arruebo, Manuel. Universidad de Zaragoza; España. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN; España
Fil: Luján, Lluis. Universidad de Zaragoza; España
Materia
ANTIBIOTIC
CONTROLLED RELEASE
HOLLOW STEEL IMPLANT
MEDICAL DEVICE
ORTHOPEDIC SURGERY
STAPHYLOCOCCUS AUREUS
Inmunología
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Nivel de accesibilidad
Acceso restringido
Licencia
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/36650