Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy

Authors
Cantón, G. J.; Konrad, José Luis; Moore, Dadin Prando; Caspe, S. G.; Palarea Albaladejo, J.; Campero, C. M.; Chianini, F.
Publication Year
2014
Language
English
Format
article
Status
Published version
Description
Neospora caninum infection in cattle stimulates host immune responses, which may be responsible for placental damage leading to abortion. Susceptibility of water buffaloes (Bubalus bubalis) to neosporosis is not well understood, although vertical transmission and fetal death have been documented. The aim of this study was to characterize the immune response in the placentome of water buffalo following experimental infection in early gestation with the Nc-1 strain of N. caninum. Placentomes were examined by immunohistochemistry using antibodies specific for T-cell subsets, natural killer cells and CD79acy cells. Placental inflammation was characterized by the infiltration of CD3+ and CD4+ T cells and T cells expressing the gd T-cell receptor. The distribution of these cellular subsets in buffalo placentomes was similar to that previously described in cattle infected with N. caninum in early gestation, but the lesions were milder, which may explain the lower number of abortions observed in this species after infection.
Fil: Cantón, G. J.. Moderun Research Institute; Reino Unido. Instituto Nacional de Tecnología Agropecuaria; Argentina
Fil: Konrad, José Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Nordeste; Argentina
Fil: Moore, Dadin Prando. Biomathematics and Statistics Scotland (BioSS); Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Caspe, S. G.. Instituto Nacional de Tecnología Agropecuaria; Argentina
Fil: Palarea Albaladejo, J.. Biomathematics and Statistics Scotland (BioSS); Reino Unido
Fil: Campero, C. M.. Instituto Nacional de Tecnología Agropecuaria; Argentina
Fil: Chianini, F.. Moderun Research Institute; Reino Unido
Subject
IMMUNITY
PLACENTOME
NEOSPORA CANINUM
BUFFALO
Otras Ciencias Veterinarias
Ciencias Veterinarias
CIENCIAS AGRÍCOLAS
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/10403