Global Genomic Diversity of Human Papillomavirus 11 Based on 433 Isolates and 78 Complete Genome Sequences

Authors
Jelen, Mateja M.; Chen, Zigui; Kocjan, Boštjan J.; Hošnjak, Lea; Burt, Felicity J.; Chan, Paul K.S.; Chouhy, Diego; Combrinck, Catharina E.; Estrade, Christine; Fiander, Alison; Garland, Suzanne M.; Giri, Adriana Angelica; González, Joaquín Víctor; Gröning, Arndt; Hibbitts, Sam; Luk, Tommy N.M.; Marinic, Karina; Matsukura, Toshihiko; Neumann, Anna; Oštrbenk, Anja; Picconi, Maria Alejandra; Sagadin, Martin; Sahli, Roland; Seedat, Riaz Y.; Seme, Katja; Severini, Alberto; Sinchi, Jessica L.; Smahelova, Jana; Tabrizi, Sepehr N.; Tachezy, Ruth; Faybush, Sarah Tohme; Uloza, Virgilijus; Uloziene, Ingrida; Wong, Yong Wee; Lepej,Snježana Židovec; Burk, Robert D.; Poljak, Mario
Publication Year
2016
Language
English
Format
article
Status
Published version
Description
Human papillomavirus 11 (HPV11) is an etiological agent of anogenital warts and laryngeal papillomas and is included in the 4-valent and 9-valent prophylactic HPV vaccines. We established the largest collection of globally circulating HPV11 isolates to date and examined the genomic diversity of 433 isolates and 78 complete genomes (CGs) from six continents. The genomic variation within the 2,800-bp E5a-E5b-L1-upstream regulatory region was initially studied in 181/207 (87.4%) HPV11 isolates collected for this study. Of these, the CGs of 30 HPV11 variants containing unique single nucleotide polymorphisms (SNPs), indels (insertions or deletions), or amino acid changes were fully sequenced. A maximum likelihood tree based on the global alignment of 78 HPV11 CGs (30 CGs from our study and 48 CGs from GenBank) revealed two HPV11 lineages (lineages A and B) and four sublineages (sublineages A1, A2, A3, and A4). HPV11 (sub)lineage-specific SNPs within the CG were identified, as well as the 208-bp representative region for CG-based phylogenetic clustering within the partial E2 open reading frame and noncoding region 2. Globally, sublineage A2 was the most prevalent, followed by sublineages A1, A3, and A4 and lineage B.
Fil: Jelen, Mateja M.. University Of Ljubljana. Faculty of Medicine. Institute Of Pathology; Argentina
Fil: Chen, Zigui. Prince Of Wales Hospital Hong Kong; Hong Kong
Fil: Kocjan, Boštjan J.. University Of Ljubljana. Faculty Of Medicine; Eslovenia
Fil: Hošnjak, Lea. University Of Ljubljana. Faculty Of Medicine; Eslovenia
Fil: Burt, Felicity J.. University Of The Free State. School Of Medicine; Sudáfrica
Fil: Chan, Paul K.S.. Prince Of Wales Hospital Hong Kong; Hong Kong
Fil: Chouhy, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Combrinck, Catharina E.. University Of The Free State. School Of Medicine; Sudáfrica
Fil: Estrade, Christine. University of Lausanne; Suiza
Fil: Fiander, Alison. Cardiff University; Reino Unido
Fil: Garland, Suzanne M.. Royal Women's Hospital, Carlton; Australia. Murdoch Children's Research Institute; Australia. University of Melbourne; Australia
Fil: Giri, Adriana Angelica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: González, Joaquín Víctor. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Gröning, Arndt. Medizinisches Versorgungszentrum Wagnerstibbe Für Laboratoriumsmedizin Und Pathologie; Alemania
Fil: Hibbitts, Sam. Cardiff University; Reino Unido
Fil: Luk, Tommy N.M.. Prince Of Wales Hospital Hong Kong; Hong Kong. Centre For Health Protection; Hong Kong
Fil: Marinic, Karina. Dr. Julio C. Perrando Hospital; Argentina
Fil: Matsukura, Toshihiko. Momate Memorial Laboratory; Japón
Fil: Neumann, Anna. Medizinisches Versorgungszentrum Wagnerstibbe Für Laboratoriumsmedizin Und Pathologie; Alemania
Fil: Oštrbenk, Anja. University Of Ljubljana. Faculty Of Medicine; Eslovenia
Fil: Picconi, Maria Alejandra. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Sagadin, Martin. University Of Ljubljana. Faculty Of Medicine; Eslovenia
Fil: Sahli, Roland. University of Lausanne; Suiza
Fil: Seedat, Riaz Y.. University Of The Free State. School Of Medicine; Sudáfrica
Fil: Seme, Katja. University Of Ljubljana. Faculty Of Medicine; Eslovenia
Fil: Severini, Alberto. National Microbiology Laboratory; Canadá
Fil: Sinchi, Jessica L.. Dr. Julio C. Perrando Hospital; Argentina
Fil: Smahelova, Jana. Institute Of Hematology And Blood Transfusion; República Checa
Fil: Tabrizi, Sepehr N.. Royal Women's Hospital, Carlton; Australia. University of Melbourne; Australia. Murdoch Children's Research Institute; Australia
Fil: Tachezy, Ruth. Institute Of Hematology And Blood Transfusion; República Checa
Fil: Faybush, Sarah Tohme. National Microbiology Laboratory; Canadá
Fil: Uloza, Virgilijus. Lithuanian University Of Health Sciences; Lituania
Fil: Uloziene, Ingrida. Lithuanian University Of Health Sciences; Lituania
Fil: Wong, Yong Wee. Universiti Kebangsaan Malaysia; Malasia
Fil: Lepej,Snježana Židovec. University Of Zagreb. School Of Medicine; Croacia
Fil: Burk, Robert D.. Albert Einstein College Of Medicine Of Yeshiva University; Estados Unidos
Fil: Poljak, Mario. University Of Ljubljana. Faculty Of Medicine; Eslovenia
Subject
HPV
HUMAN PAPILLOMAVIRUS
HPV11
GENOMIC DIVERSITY
GENETIC DIVERSITY
COMPLETE GENOME
DNA SEQUENCING
WORLDWIDE
GLOBAL
Otras Ciencias Biológicas
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Bioquímica y Biología Molecular
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/66660