A Novel Bone Scaffolds Based on Hyperbranched Polyglycerol Fibers Filled with Hydroxyapatite Nanoparticles: In Vitro Cell Response

Authors
Alencar de Queiroz, Alvaro Antonio; Bressiani, José Carlos; Bressiani, Ana Helena A.; Higa, Olga Z.; Abraham, Gustavo Abel
Publication Year
2008
Language
English
Format
article
Status
Published version
Description
A novel bone scaffolding material was successfully fabricated by electrospinning from hyperbranched polyglycerol (HPGL) solutions containing nanoparticles of hydroxyapatite (HA). The potential use of the electrospun fibrous HPGL-HA scaffolds for bone regeneration was evaluated in vitro with human osteoblasts in terms of alkaline phosphatase (ALP) activity of the cells that were cultured directly on the scaffolds. The results were compared with those on corresponding HPLG-HA solution-cast film scaffolds. It was found that all of the fibrous scaffolds promoted much better adhesion and proliferation of cells than the corresponding film scaffolds.
Fil: Alencar de Queiroz, Alvaro Antonio. Universidade Federal de Itajubá; Brasil
Fil: Bressiani, José Carlos. Comissao Nacional de Energia Nuclear. Centro de Lasers e Aplicacoes. Instituto de Pesquisas Energeticas e Nucleares.; Brasil
Fil: Bressiani, Ana Helena A.. Comissao Nacional de Energia Nuclear. Centro de Lasers e Aplicacoes. Instituto de Pesquisas Energeticas e Nucleares.; Brasil
Fil: Higa, Olga Z.. Comissao Nacional de Energia Nuclear. Centro de Lasers e Aplicacoes. Instituto de Pesquisas Energeticas e Nucleares.; Brasil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Subject
SCAFFOLDS
NANOCOMPOSITES
ELECTROSPINNING
Biotecnología Industrial
Biotecnología Industrial
INGENIERÍAS Y TECNOLOGÍAS
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/66832