Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review

Authors
Verdes, Jose M.; Riet Correa, Franklin; Medeiros, Rosane M.T.; Moraña, Antonio; Battes, Daniel; Dehl, Virginia; Borteiro, Claudio; Gimeno, Eduardo Juan; Sant’Ana, Fabiano J.F.; Barros, Claudio S.L.; Barros, Servero S.
Publication Year
2013
Language
English
Format
article
Status
Published version
Description
Cattle that consume Solanum bonariense L (= Solanum fastigiatum Willd.) or Solanum paniculatum L. develop a typical cerebellar cortical degeneration characterized by periodic episodes of ataxia, hypermetria, hyperesthesia, head and thoracic limb extension, opisthotonus, nystagmus, and falling to the side or backward. Histological lesions include vacuolation, degeneration, and loss of Purkinje cells. Axonal spheroids, microcavitations, and other changes of Wallerian degeneration in cerebellar granular layer and white matter are also observed. Neurotoxic compounds in Solanum spp. causing neurologic dysfunction in ruminants were not definitively elucidated. The same Solanaceae species are extensively used with culinary purposes or for the treatment of liver and gastrointestinal disorders as hangovers in humans. In the present paper, we review the epidemiology, clinical signs, and pathological hallmarks of poisoning by Solanum —S. bonariense L. (=S. fastigiatum Willd.) and S. paniculatum—with emphasis in histopathology, ultrastructural, and lectin- and immuno-histochemical changes in spontaneous and experimentally poisoned cattle in South America. The current knowledge of the pathogenesis of these bovine cerebellar cortical degenerations is discussed, and some advances in botanical and toxicological aspects of these Solanaceae species are presented, taking into account the potential risk of human poisoning.
Fil: Verdes, Jose M.. Universidad de la República; Uruguay
Fil: Riet Correa, Franklin. Federal University of Campina Grande; Brasil
Fil: Medeiros, Rosane M.T.. Federal University of Campina Grande; Brasil
Fil: Moraña, Antonio. Universidad de la República; Uruguay
Fil: Battes, Daniel. Universidad de la República; Uruguay
Fil: Dehl, Virginia. Universidad de la República; Uruguay
Fil: Borteiro, Claudio. Universidad de la República; Uruguay
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sant’Ana, Fabiano J.F.. Universidade Federal de Goiás; Brasil
Fil: Barros, Claudio S.L.. Federal University of Santa Maria; Brasil
Fil: Barros, Servero S.. Federal University of Santa Maria; Brasil
Subject
cerebellar degeneration
diseases of cattle
poisonous plants
Solanacae
Otras Ciencias Veterinarias
Ciencias Veterinarias
CIENCIAS AGRÍCOLAS
Access level
Open access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/23955