Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging

Authors
Koehler, Niklas K. U.; Stransky, Elle; Meyer, Mirjam; Gaertner, Susanne; Shing, Mona; Schnaidt, Martina; Celej, Maria Soledad; Jovin, Thomas M.; Leyhe, Thomas; Laske, Christoph; Batra, Anil; Buchkremer, Gerhard; Fallgatter, Andreas J.; Wernet, Dorothee; Richartz Salzburger, Elke
Publication Year
2015
Language
English
Format
article
Status
Published version
Description
There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies. These disorders present with a variable extent of cognitive impairment and alpha-synuclein is being explored as a biomarker in CSF, blood serum and plasma. Considering key events of aging that include proteostasis, alpha-synuclein may not only be useful as a marker for differential diagnosis but also for aging per se. To explore this hypothesis, we developed a highly specific ELISA to measure alpha-synuclein. In healthy males plasma alpha-synuclein levels correlated strongly with age, revealing much lower concentrations in older (avg. 58.1 years) compared to younger (avg. 27.6 years) individuals. This difference between the age groups was enhanced after acidification of the plasmas (p<0.0001), possibly reflecting a decrease of alpha-synuclein-antibody complexes or chaperone activity in older individuals. Our results support the concept that alpha-synuclein homeostasis may be impaired early on, possibly due to disturbance of the proteostasis network, a key component of healthy aging. Thus, alpha-synuclein may be a novel biomarker of aging, a factor that should be considered when analyzing its presence in biological specimens.
Fil: Koehler, Niklas K. U.. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. German Center for Neurodegenerative Diseases; Alemania
Fil: Stransky, Elle. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Meyer, Mirjam. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Gaertner, Susanne. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Shing, Mona. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Schnaidt, Martina. Zentrum für Klinische Transfusionsmedizin; Alemania
Fil: Celej, Maria Soledad. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Quimica Biológica; Argentina. Institute for Biophysical Chemistry. Laboratory for Cellular Dynamics, Max-Planck; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Química Biológica de Córdoba (p); Argentina
Fil: Jovin, Thomas M.. Institute for Biophysical Chemistry. Laboratory for Cellular Dynamics, Max-Planck; Alemania
Fil: Leyhe, Thomas. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. Psychiatric University Hospital. Center of Old Age Psychiatry; Alemania
Fil: Laske, Christoph . Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. German Center for Neurodegenerative Diseases; Alemania
Fil: Batra, Anil. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Buchkremer, Gerhard. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Fallgatter, Andreas J.. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Wernet, Dorothee. Zentrum für Klinische Transfusionsmedizin; Alemania
Fil: Richartz Salzburger, Elke. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Subject
ALPHA-SYNUCLEIN
PARKINSON
BLOOD PLASMA
BIOMARKER
Neurociencias
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Open access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/10653