Type I and Type II Photosensitized Oxidation Reactions: Guidelines and Mechanistic Pathways

Authors
Baptista, Maurício S.; Cadet, Jean; Di Mascio, Paolo; Ghogare, Ashwini A.; Greer, Alexander; Hamblin, Michael R.; Lorente, Carolina; Nunez, Silvia Cristina; Simoes Ribeiro, Martha; Thomas, Andrés Héctor; Vignoni, Mariana; Yoshimura, Tania Mateus
Publication Year
2017
Language
English
Format
article
Status
Published version
Description
Here, 10 guidelines are presented for a standardized definition of type I and type II photosensitized oxidation reactions. Because of varied notions of reactions mediated by photosensitizers, a checklist of recommendations is provided for their definitions. Type I and type II photoreactions are oxygen-dependent and involve unstable species such as the initial formation of radical cation or neutral radicals from the substrates and/or singlet oxygen (1O2 1∆g) by energy transfer to molecular oxygen. In addition, superoxide anion radical (O.- 2) can be generated by a charge-transfer reaction involving O2 or more likely indirectly as the result of O2-mediated oxidation of the radical anion of type I photosensitizers. In subsequent reactions, O.- 2 may add and/or reduce a few highly oxidizing radicals that arise from the deprotonation of the radical cations of key biological targets.O.- 2 can also undergo dismutation into H2O2, the precursor of the highly reactive hydroxyl radical (.OH) that may induce delayed oxidation reactions in cells. In the second part, several examples of type I and type II photosensitized oxidation reactions are provided to illustrate the complexity and the diversity of the degradation pathways of mostly relevant biomolecules upon one-electron oxidation and singlet oxygen reactions.
Fil: Baptista, Maurício S.. Universidade de Sao Paulo; Brasil
Fil: Cadet, Jean. University of Sherbrooke; Canadá
Fil: Di Mascio, Paolo. Universidade de Sao Paulo; Brasil
Fil: Ghogare, Ashwini A.. Brooklyn College; Estados Unidos. City University of New York; Estados Unidos
Fil: Greer, Alexander. Brooklyn College; Estados Unidos. City University of New York; Estados Unidos
Fil: Hamblin, Michael R.. Massachusetts General Hospital; Estados Unidos. Harvard Medical School; Estados Unidos
Fil: Lorente, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Nunez, Silvia Cristina. Universidade Camilo Castelo Branco; Brasil
Fil: Simoes Ribeiro, Martha. Comissao Nacional de Energia Nuclear. Centro de Lasers e Aplicacoes. Instituto de Pesquisas Energeticas e Nucleares.; Brasil
Fil: Thomas, Andrés Héctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Vignoni, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Yoshimura, Tania Mateus. Comissao Nacional de Energia Nuclear. Centro de Lasers e Aplicacoes. Instituto de Pesquisas Energeticas e Nucleares.; Brasil
Subject
reactive oxygen species
radicals
singlet oxygen
superoxide anion
Otras Ciencias Químicas
Ciencias Químicas
CIENCIAS NATURALES Y EXACTAS
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/64008