Staphylococcus aureus adaptation to the host and persistence: Role of loss of capsular polysaccharide expression

Authors
Tuchscherr, Lorena Paola Nelly; Lffler, Bettina; Buzzola, Fernanda Roxana; Sordelli, Daniel Oscar
Publication Year
2010
Language
English
Format
article
Status
Published version
Description
A vast array of virulence factors enable Staphylococcus aureus to readily adapt to different environmental niches in diverse hosts. The cap gene cluster is present in almost all relevant clinical S. aureus isolates and capsular polysaccharide expression is apparent in isolates from patients with acute infection. The number of S. aureus isolates from patients with chronic infections that do not express capsular polysaccharide, however, is significantly high, indicating that loss of capsular polysaccharide expression may be a key S. aureus feature associated with persistence. The role of the loss of capsular polysaccharide expression as well as the emergence of other defined phenotypes and their relevance to persistence of S. aureus and chronicity of the infection is discussed in this article. © 2010 Future Medicine Ltd.
Fil: Tuchscherr, Lorena Paola Nelly. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universitätsklinikum Münste; Alemania
Fil: Lffler, Bettina. Universitätsklinikum Münste; Alemania
Fil: Buzzola, Fernanda Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Sordelli, Daniel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Subject
CAPSULE
CHRONIC
EVOLUTION
INFECTION
PERSISTENCE
STAPHYLOCOCCUS AUREUS
Otras Medicina Básica
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/67627