Arene cis-Diol Dehydrogenase-Catalysed Regio- and Stereoselective Oxidation of Arene-, Cycloalkane- and Cycloalkene-cis-diols to Yield Catechols and Chiral α-Ketols

Authors
Boyd, Derek R.; Sharma, Narain D.; Berberian, Victoria; Cleij, Marcel; Hardacre, Christopher; Ljubez, Vera; McConville, Gareth; Stevenson, Paul J.; Kulakov, Leonid A.; Allen, Christopher C. R.
Publication Year
2015
Language
English
Format
article
Status
Published version
Description
Benzene cis-diol dehydrogenase and naphthalene cis-diol dehydrogenase enzymes, expressed in Pseudomonas putida wild-type and Escherichia coli recombinant strains, were used to investigate regioselectivity and stereoselectivity during dehydrogenations of arene, cyclic alkane and cyclic alkene vicinal cis-diols. The dehydrogenase-catalysed production of enantiopure cis-diols, α-ketols and catechols, using benzene cis-diol dehydrogenase and naphthalene cis-diol dehydrogenase, involved both kinetic resolution and asymmetric synthesis methods. The chemoenzymatic production and applications of catechol bioproducts in synthesis were investigated.
Fil: Boyd, Derek R.. The Queens University of Belfast; Irlanda
Fil: Sharma, Narain D.. The Queens University of Belfast; Irlanda
Fil: Berberian, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. The Queens University of Belfast; Irlanda
Fil: Cleij, Marcel. The Queens University of Belfast; Irlanda
Fil: Hardacre, Christopher. The Queens University of Belfast; Irlanda
Fil: Ljubez, Vera. The Queens University of Belfast; Irlanda
Fil: McConville, Gareth. The Queens University of Belfast; Irlanda
Fil: Stevenson, Paul J.. The Queens University of Belfast; Irlanda
Fil: Kulakov, Leonid A.. The Queens University of Belfast; Irlanda
Fil: Allen, Christopher C. R.. The Queens University of Belfast; Irlanda
Subject
ALKENE-/ARENE-CIS-1,2-DIOLS
CATECHOLS
CIS-DIOL DEHYDROGENASES
STEREOSELECTIVITY
Α-KETOLS
Otras Ciencias Químicas
Ciencias Químicas
CIENCIAS NATURALES Y EXACTAS
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/60080