Congenital Chagas disease: An update

Authors
Carlier, Yves; Sosa-Estani, Sergio Alejandro; Luquetti, Alejandro O; Buekens, Pierre
Publication Year
2015
Language
English
Format
article
Status
Published version
Description
Congenital infection with Trypanosoma cruzi is a global problem, occurring on average in 5% of children born from chronically infected mothers in endemic areas, with variations depending on the region. This presentation aims to focus on and update epidemiological data, research methods, involved factors, control strategy and possible prevention of congenital infection with T. cruzi. Considering that etiological treatment of the child is always effective if performed before one year of age, the diagnosis of infection in pregnant women and their newborns has to become the standard of care and integrated into the surveillance programs of syphilis and human immunodeficiency virus. In addition to the standard tests, polymerase chain reaction performed on blood of neonates of infected mothers one month after birth might improve the diagnosis of congenital infection. Recent data bring out that its transmission can be prevented through treatment of infected women before they become pregnant. The role of parasite genotypes and host genetic factors in parasite transmission and development of infection in foetuses/neonates has to be more investigated in order to better estimate the risk factors and impact on health of congenital infection with T. cruzi.
Fil: Carlier, Yves. Université Libre de Bruxelles; Bélgica. University of Tulane; Estados Unidos
Fil: Sosa-Estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Luquetti, Alejandro O. Universidade Federal de Goiás; Brasil
Fil: Buekens, Pierre. University of Tulane; Estados Unidos
Subject
CONGENITAL CHAGAS DISEASE
CONGENITAL T. CRUZI INFECTION
MATERNAL-FOETAL TRANSMISSION
TRYPANOSOMA CRUZI
Salud Ocupacional
Ciencias de la Salud
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Open access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/39809