A role for ΔfosB in calorie restriction-induced metabolic changes

Authors
Vialou, Vincent F.; Cui, Huxing; Perello, Mario; Mahgoub, Melissa A.; Yu, Hana G.; Rush, Augustus J.; Pranav, Heena; Jung, Saendy; Yangisawa, Masashi; Zigman, Jeffrey M.; Elmquist, Joel K.; Nestler, Eric J.; Lutter, Michael
Publication Year
2011
Language
English
Format
article
Status
Published version
Description
Background: Calorie restriction (CR) induces long-term changes in motivation to eat highly palatable food and, in body weight regulation, through an unknown mechanism. Methods: After a period of CR and refeeding, mice were assessed by behavioral and metabolic studies and for levels of the transcription factor ΔFosB. The ΔFosB levels were then increased specifically in nucleus accumbens (NAc) with viral-mediated gene transfer, and behavioral and metabolic studies were conducted. Results: We show that accumulation of ΔFosB in the NAc shell after CR in mice corresponds to a period of increased motivation for high fat reward and reduced energy expenditure. Furthermore, ΔFosB overexpression in this region increases instrumental responding for a high fat reward via an orexin-dependent mechanism while also decreasing energy expenditure and promoting adiposity. Conclusions: These results suggest that ΔFosB signaling in NAc mediates adaptive responses to CR.
Fil: Vialou, Vincent F.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados Unidos
Fil: Cui, Huxing. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Perello, Mario. University of Texas. Southwestern Medical Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Mahgoub, Melissa A.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Yu, Hana G.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Rush, Augustus J.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Pranav, Heena. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Jung, Saendy. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Yangisawa, Masashi. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Zigman, Jeffrey M.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Elmquist, Joel K.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Nestler, Eric J.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados Unidos
Fil: Lutter, Michael. University of Texas. Southwestern Medical Center; Estados Unidos
Subject
APPETITE
FEEDING
METABOLISM
NUCLEUS ACCUMBENS
OREXIN
Neurociencias
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Open access
License
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/85917