Anticipating hyperthermic efficiency of magnetic colloids using a semi-empirical model: A tool to help medical decisions

Authors
Fernández van Raap, Marcela Beatriz; Coral, Diego Fernando; Yu, S.; Muñoz Medina, Guillermo Arturo; Sánchez, Francisco Homero; Roig, A.
Publication Year
2017
Language
English
Format
article
Status
Published version
Description
Magnetic hyperthermia, a modality that uses radio frequency heating assisted with single-domain magnetic nanoparticles, is becoming established as a powerful oncological therapy. Much improvement in nanomaterials development, to enhance their heating efficiency by tuning the magnetic colloidal properties, has been achieved. However, methodological standardization to accurately and univocally determine the colloidal properties required to numerically reproduce a specific heating efficiency using analytical expressions still holds. Thus, anticipating the hyperthermic performances of magnetic colloids entails high complexity due to polydispersity, aggregation and dipolar interactions always present in real materials to a greater or lesser degree. Here, by numerically simulating the experimental results and using real biomedical aqueous colloids, we analyse and compare several approaches to reproduce experimental specific absorption rate values. Then, we show that the relaxation time, determined using a representative mean activation energy consistently derived from four independent experiments accurately reproduces experimental heating efficiencies. Moreover, the so-derived relaxation time can be used to extrapolate the heating performance of the magnetic nanoparticles to the other field conditions within the framework of the linear response theory. We thus present a practical tool that may truly aid the design of medical decisions.
Fil: Fernández van Raap, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Coral, Diego Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Yu, S.. Consejo Superior de Investigaciones Científicas; España
Fil: Muñoz Medina, Guillermo Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Sánchez, Francisco Homero. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Roig, A.. Consejo Superior de Investigaciones Científicas; España
Subject
magnetic hyperthermia
magnetic nanoparticles
medical support
Nano-materiales
Nanotecnología
INGENIERÍAS Y TECNOLOGÍAS
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/54412