Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis

Authors
Carrillo Muñoz, Alfonso Javier; Tur Tur, Cristina; Giusiano, Gustavo Emilio; Marcos Arias, Cristina; Eraso, Elena; Jauregizar, Nerea; Quindós, Guillermo
Publication Year
2013
Language
English
Format
article
Status
Published version
Description
Sertaconazole is a useful antifungal agent against mycoses of the skin and mucosa, such as cutaneous, genital and oral candidiasis and tinea pedis. Its antifungal activity is due to inhibition of the ergosterol biosynthesis and disruption of the cell wall. At higher concentrations, sertaconazole is able to bind to nonsterol lipids of the fungal cell wall, increasing the permeability and the subsequent death of fungal cells. Fungistatic and fungicidal activities on Candida are dose-dependent. The antifungal spectrum of sertaconazole includes deramophytes, Candida, Cryptococcus, Malassezia and also Aspergillus, Scedosporium and Scopulariopsis. Sertaconazole also shows an antimicrobial activity against streptococci, staphylococci and protozoa (Trichomonas). In clinical trials including patients with vulvovaginal candidiasis, a single dose of sertaconazole produced a higher cure rate compared with other topical azoles such as econazole and clotrimazole, in shorter periods. Sertaconazole has shown an anti-inflammatory effect that is very useful for the relief of unpleasant symptoms
Fil: Carrillo Muñoz, Alfonso Javier. Departamento de Microbiología-Micología, ACIAM,; España
Fil: Tur Tur, Cristina. SDPI CAP Manso; España
Fil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marcos Arias, Cristina. Universidad del País Vasco-Euskal Herriko Unibertsitatea; España
Fil: Eraso, Elena. Universidad del País Vasco-Euskal Herriko Unibertsitatea; España
Fil: Jauregizar, Nerea. Universidad del País Vasco-Euskal Herriko Unibertsitatea; España
Fil: Quindós, Guillermo. Universidad del País Vasco-Euskal Herriko Unibertsitatea; España
Subject
ANTIFUNGAL
AZOLES
CANDIDA
SERTACONAZOLE
Micología
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/8943