Circaannual changes in antioxidants and oxidative stress in the heart and liver in rats

Authors
Belló Klein, A.; Morgan Martins, M. I.; Barp, J.; Llesuy, Susana Francisca; Bello, A. A.; Singal, P. K.
Publication Year
2000
Language
English
Format
article
Status
Published version
Description
Reactive oxygen species are formed in physiological and pathological conditions in mammalian tissues. Because of their high reactivity, they may interact with biomolecules, inducing oxidative injury. Increases in lipid peroxidation can result in oxidative damage to cellular membranes. Protection against oxidative damage is provided by enzymatic and non-enzymatic antioxidant defenses. Antioxidant enzyme activities and lipid peroxidation, as an index of oxidative stress injury, were evaluated in different seasons over one year in the heart and liver of rats, maintained on a 12 h light and dark cycle. Glutathione peroxidase and catalase activities, in both tissues, were maximal in the summer season. Lipid peroxidation in the heart was maximal in the spring as compared to the other seasons and it did not vary in the liver during the year. These findings suggest that any study of antioxidants or oxidative stress must take into account such seasonal variations for a more precise analysis of changes due to any pathological condition. © 2000 Elsevier Science Inc. All rights reserved.
Fil: Belló Klein, A.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; Brasil
Fil: Morgan Martins, M. I.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; Brasil
Fil: Barp, J.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Bello, A. A.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; Brasil
Fil: Singal, P. K.. St Boniface General Hospital Research Centre; Canadá
Subject
Catalase
Glutathione peroxidase (GSHPx)
Lipid peroxidation
Seasonal variations
Otras Ciencias Biológicas
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/44493