Activation of central melanocortin pathways by fenfluramine

Authors
Heisler, Lora K.; Cowley, Michael A.; Tecott, Laurence H.; Fan, Wei; Low, Malcolm J.; Smart, James L.; Rubinstein, Marcelo; Tatro, Jeffrey B.; Marcus, Jacob N.; Holstege, Henne; Lee, Charlotte E.; Cone, Roger D.; Elmquist, Joel K.
Publication Year
2002
Language
English
Format
article
Status
Published version
Description
D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective weight loss drugs, but was withdrawn from clinical use because of reports of cardiac complications in a subset of patients. Discerning the neurobiology underlying the anorexic action of d-FEN may facilitate the development of new drugs to prevent and treat obesity. Through a combination of functional neuroanatomy, feeding and electrophysiology studies in rodents, we show that d-FEN-induced anorexia requires activation of central nervous system melanocortin pathways. These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective antiobesity treatments.
Fil: Heisler, Lora K.. Harvard Medical School; Estados Unidos
Fil: Cowley, Michael A.. Oregon Health and Science University; Estados Unidos
Fil: Tecott, Laurence H.. University of California; Estados Unidos
Fil: Fan, Wei. Oregon Health and Science University; Estados Unidos
Fil: Low, Malcolm J.. Oregon Health and Science University; Estados Unidos
Fil: Smart, James L.. Oregon Health and Science University; Estados Unidos
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Tatro, Jeffrey B.. Tufts University School of Medicine; Estados Unidos
Fil: Marcus, Jacob N.. Harvard Medical School; Estados Unidos
Fil: Holstege, Henne. Harvard Medical School; Estados Unidos
Fil: Lee, Charlotte E.. Harvard Medical School; Estados Unidos
Fil: Cone, Roger D.. Oregon Health and Science University; Estados Unidos
Fil: Elmquist, Joel K.. Harvard Medical School; Estados Unidos
Subject
serotonina
melanocortinas
Neurociencias
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/79913