Effects of parboiled rice diet on oxidative stress parameters in kidney of rats with streptozotocin-induced diabetes

Authors
Finamor, Isabela A.; Saccol, Etiane M. H.; Gabriel, Diogo; Ourique, Giovana M.; Riffel, Ana P.K.; Konrad, Signorá P.; Belló Klein, Adriane; Partata, Wania; Baldisserotto, Bernardo; Llesuy, Susana Francisca; Pavanato, Maria A.
Publication Year
2012
Language
English
Format
article
Status
Published version
Description
The effect of parboiled rice (PR) and white rice (WR) diets on oxidative stress (OS) parameters was investigated in the kidneys of rats with streptozotocin-induced diabetes (40mg kg-1, iv). The experimental groups (n=8) were control fed with PR (CPR), control fed with WR, diabetic fed with PR, and diabetic fed with WR. After 30 days of treatment, all animals were anesthetized and exsanguinated before removal of kidneys, which were used to determine thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides, carbonyl protein, superoxide dismutase, catalase, glutathione peroxidase (GPx), glutathione reductase, glutathione-S-transferase activities, and levels of glutathione (GSH). Total phenolic compounds were determined in WR and PR grains. Our data indicated that diabetes induced increase in TBARS and lipid hydroperoxides levels. Although PR has not prevented the rise in the levels of these measurements, its consumption by our animals resulted in higher GPx activity and GSH content than that of the CPR. Moreover, PR also presented concentration of total phenolic compounds 127% higher than WR grains. Thus, its consumption in this diabetic condition is suggested because this seems to confer greater protection against OS in the renal tissue of diabetic animals. © Copyright 2012, Mary Ann Liebert, Inc.
Fil: Finamor, Isabela A.. Federal University of Santa Maria; Brasil
Fil: Saccol, Etiane M. H.. Federal University of Santa Maria; Brasil
Fil: Gabriel, Diogo. Federal University of Santa Maria; Brasil
Fil: Ourique, Giovana M.. Federal University of Santa Maria; Brasil
Fil: Riffel, Ana P.K.. Federal University of Santa Maria; Brasil
Fil: Konrad, Signorá P.. University of Vale do Rio dos Sinos; Brasil
Fil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Partata, Wania. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Baldisserotto, Bernardo. Federal University of Santa Maria; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica; Argentina
Fil: Pavanato, Maria A.. Federal University of Santa Maria; Brasil
Subject
DIABETES
KIDNEY
OXIDATIVE STRESS
PARBOILED RICE
WHITE RICE
Salud Ocupacional
Ciencias de la Salud
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/67397