Evaluation of kinetic behaviour of two preparations of tylosin administered in beehives for American foulbrood control

Authors
Reynaldi, Francisco José; Albo, G.; Avellaneda, E.; Rule, R.
Publication Year
2016
Language
English
Format
article
Status
Published version
Description
We compared the kinetic behaviour of tylosin administered to beehives by dusting or paper-pack placement through three treatment protocols (D, PP, CONTROL). D (dusting): tylosin, divided in four portions, was sprinkled over the ends of the hives' top bars weekly for four weeks (n=3); PP (paper-pack placement): tylosin in paper packs was administered at two-week intervals (n=3); CONTROL (control): the hives were left untreated (n=3). In every inspection, from each of the nine hives, fifty young (2-day-old) larvae were sampled for drug analysis. The concentration of tylosin in the young larvae was determined by a microbiological assay with Geobacillus stearothermophilus ATCC 12980 as test organism. The (mean±SD) maximum concentration (Cmax) for D was 136.0±194.0 and for PP – 144.0±187.4 μg/mL; the time to reach Cmax (tmax) was 1.5±0.9 h for D and 1.8 ± 1.8 h for PP. The area under the tylosin behaviour kinetics curve between 0–1392 h with D was 308.7±185.2 and with PP: 326.4±141.0 μg/h/mL, indicating no statistical difference between the treatments (P>0.05). The shorter duration of paper-pack-administered tylosin observed in the larvae implied a lower risk of antibiotic residues in the resulting honey.
Fil: Reynaldi, Francisco José. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Albo, G.. Universidad Nacional de La Plata. Facultad de Ciencias Agrarias y Forestales; Argentina
Fil: Avellaneda, E.. Universidad Nacional de La Plata. Facultad de Ciencias Agrarias y Forestales; Argentina
Fil: Rule, R.. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Subject
AMERICAN FOULBROOD
BEEHIVES
KINETICS
TYLOSIN
Otras Ciencias Veterinarias
Ciencias Veterinarias
CIENCIAS AGRÍCOLAS
Access level
Open access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/54744