Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF

Authors
Agostino, Patricia; Cheng, C. K.; Williams, C. L.; West, A. E.; Meck, W. H.
Publication Year
2013
Language
English
Format
article
Status
Published version
Description
Interval timing within the seconds-to-minutes range involves the interaction of the prefrontal cortex and basal ganglia via dopaminergic-glutamatergic pathways. Because the secreted protein BDNF is able to modulate dopamine release as well as glutamatergic activity, we hypothesized that BDNF may be important for these timing mechanisms. Recently the transcription factor CaRF was identified as an important modulator of BDNF expression in the cerebral cortex. In the present study, a strain of Carf knockout mice were evaluated for their ability to acquire the "Start" and "Stop" response thresholds under sequential and simultaneous training conditions, using multiple (15-s and 45-s) or single (30-s) target durations using the peak-interval procedure. Both Carf+/- and Carf-/- mice were impaired in their ability to acquire timed response thresholds relative to Carf+/+ mice. These results suggest that the inhibitory processes required to set response thresholds and exert temporal control of behavior may be dependent on CaRF regulation of genes including Bdnf in cortico-striatal circuits.
Fil: Agostino, Patricia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cheng, C. K.. A*STAR/Duke-NUS Neuroscience Research Partnership; Singapur
Fil: Williams, C. L.. Duke University. Department of Psychology and Neuroscience; Estados Unidos
Fil: West, A. E.. Duke University. Department of Neurobiology; Estados Unidos
Fil: Meck, W. H.. Duke University. Department of Psychology and Neuroscience; Estados Unidos
Subject
TIMING AND TIME PERCEPTION
GLUTAMATE
DOPAMINE
CALCIUM-RESPONSIVE TRANSCRIPTION FACTOR
Neurociencias
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/3204