A control systems analysis of HIV prevention model using impulsive input

Authors
Chang, H.J.; Moog, Claude; Astolfi, Alessandro; Rivadeneira Paz, Pablo Santiago
Publication Year
2014
Language
English
Format
article
Status
Published version
Description
We investigate a control systems analysis on HIV infection dynamics with regard to enhancement of theimmune response. The HIV dynamic model is modified to include the pharmacokinetics and pharma-codynamics of antiretroviral HIV drugs, and the intake of drug is considered as impulsive control input.As it is administrated at discrete time instants, we assume that this yields an impulsive control problemfor a nonlinear continuous-time system. Based on this new model, we study clinical experiments aboutantirretoviral treatments via numerical simulation and analyse the experimental results. It is noted thatthis modeling approach can help to provide a theoretical explanation of the clinical results. The analysisresult in the paper could imply that the protocol of the experiment might enhance the immune responseagainst HIV.
Fil: Chang, H.J.. Kookmin University; Corea del Sur
Fil: Moog, Claude. Centre de Recherche de Nantes; Francia
Fil: Astolfi, Alessandro. Imperial College London; Reino Unido. Universita Tor Vergata; Italia
Fil: Rivadeneira Paz, Pablo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina
Subject
Biological systems
Disease dynamics
HIV
Control systems
Sistemas de Automatización y Control
Ingeniería Eléctrica, Ingeniería Electrónica e Ingeniería de la Información
INGENIERÍAS Y TECNOLOGÍAS
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/9286