Acilación quimioselectiva de hidroxialcanotioles catalizada por lipasas en medio orgánico

Autores
Iglesias, Luis Emilio
Año de publicación
1996
Idioma
español
Tipo de recurso
tesis doctoral
Estado
Versión publicada
Director/a de tesis
Gros, Eduardo Gervasio
Baldessari, Alicia
Descripción
Various bi- and polifunctional hydroxyalkanethiols were chemospecifically acylated to O-acylesters by lipase-catalyzed transesterifications in organic media. In addition, hydroxyalkanethiols with two hydroxyl groups exhibited regiospecificity or regioselectivity, depending on the nature of both the substrate and the lipase. As the chain length of the α,ω-hydroxyalkanethiol increased, the reaction was limited to smaller acyl moieties. Experimental conditions under which enzymatic acylations were carried out and their results are presented and discussed. Biocatalyzed transesterifications allowed the preparation of twenty-four new esters. The preparation of some α,ω-hydroxyalkanethiols and the mass spectra of substrates and products are also presented and discussed.
Fil:Iglesias, Luis Emilio. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Materia
LIPASES
ORGANIC MEDIA
HYDROXYALKANETHIOLS
SELECTIVE ACYLATION
TRANSESTERIFICATION
Nivel de accesibilidad
Acceso abierto
Licencia
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
snrd:Tesis_2856_Iglesias