Authors: Trinks, Julieta; Nishida, Nao; Hulaniuk, María Laura; Caputo, Mariela; Tsuchiura, Takayo; Marciano, Sebastián; Haddad, Leila; Blejer, Jorgelina L.; Bartoli, Sonia; Ameigeiras, Beatriz; Frías, Silvia E.; Vistarini, Cecilia; Heinrich, Fabiana; Remondegui, Carlos; Ceballos, Susana; Echenique, Gustavo; Charre Samman, Miguel; D'Amico, Claudia; Rojas, Amalia; Martínez, Alfredo; Ridruejo, Ezequiel; Fernandez, Roberto Julio; Burgos Pratx, Leandro; Salamone, Horacio J.; Nuñez, Felix A.; Galdame, Omar; Gadano, Adrián Carlos; Corach, Daniel; Sugiyama, Masaya; Flichman, Diego Martin; Tokunaga, Katsushi; Mizokami, Masashi
Publication Date: 2017.
Language: English.
Abstract:
Background & Aims: HBV infection exhibits geographical variation in its distribution in South America. While HBV rates are low in central Argentina, the north-western region exhibits intermediate HBV rates. Unfortunately, the reasons that could explain this difference are still unknown. Methods: a total of 1440 Argentines were recruited and grouped into HBV patients, HBV-resolved individuals and healthy controls. Genetic ancestry was assessed by analysis of biparental lineages and ancestry autosomal typing. SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were determined, and HBV genotyping was performed by phylogenetic analysis in HBV patients. Results: Native American ancestry prevailed in the north-western region when compared with central Argentina (P<.0001). However, no differences were observed among the three groups of each region. The distribution of HBV genotypes revealed significant differences (P<.0001). Three SNPs (rs3077, rs9277542 and rs7453920) showed a significant association with protection against chronic HBV and viral clearance in both regions. The remaining SNP showed a significant association with susceptibility to chronic HBV. The frequency rates of rs3077-T, related to protection against chronic HBV and viral clearance, were lower in north-western Argentina when compared with central Argentina. The same uneven frequency rates were observed for SNP rs9277542. Conclusions: this is the first study addressing the associations between the HLA-DP and HLA-DQ loci and the protection against chronic HBV and viral clearance in a multiethnic South American population. The uneven distribution of HLA-DP and HLA-DQ supports the HBV epidemiological differences observed in these two regions of Argentina with dissimilar ancestry genetic background.
Author affiliation: Trinks, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina
Author affiliation: Nishida, Nao. National Center for Global Health and Medicine; Japón. University of Tokyo; Japón
Author affiliation: Hulaniuk, María Laura. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina
Author affiliation: Caputo, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina
Author affiliation: Tsuchiura, Takayo. National Center for Global Health and Medicine; Japón
Author affiliation: Marciano, Sebastián. Hospital Italiano; Argentina
Author affiliation: Haddad, Leila. Hospital Italiano; Argentina
Author affiliation: Blejer, Jorgelina L.. Fundación Hemocentro Buenos Aires; Argentina
Author affiliation: Bartoli, Sonia. Provincia de Jujuy. Hospital Pablo Soria. Unidad de Hemoterapia; Argentina
Author affiliation: Ameigeiras, Beatriz. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; Argentina
Author affiliation: Frías, Silvia E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; Argentina
Author affiliation: Vistarini, Cecilia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; Argentina
Author affiliation: Heinrich, Fabiana. Provincia de Entre Ríos. Hospital San Antonio; Argentina
Author affiliation: Remondegui, Carlos. Provincia de Jujuy. Hospital San Roque; Argentina
Author affiliation: Ceballos, Susana. Provincia de Jujuy. Hospital San Roque; Argentina
Author affiliation: Echenique, Gustavo. Clínica Nuestra Señora del Rosario; Argentina
Author affiliation: Charre Samman, Miguel. Laboratorio Central de Salud Pública; Argentina
Author affiliation: D'Amico, Claudia. Centro de Especialidades Médicas Ambulatorias; Argentina
Author affiliation: Rojas, Amalia. Centro de Especialidades Médicas Ambulatorias; Argentina
Author affiliation: Martínez, Alfredo. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
Author affiliation: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas ; Argentina
Author affiliation: Fernandez, Roberto Julio. Fundación Hemocentro Buenos Aires; Argentina
Author affiliation: Burgos Pratx, Leandro. Hospital Italiano; Argentina
Author affiliation: Salamone, Horacio J.. Hospital Italiano; Argentina
Author affiliation: Nuñez, Felix A.. Hospital Italiano; Argentina
Author affiliation: Galdame, Omar. Hospital Italiano; Argentina
Author affiliation: Gadano, Adrián Carlos. Hospital Italiano; Argentina
Author affiliation: Corach, Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina
Author affiliation: Sugiyama, Masaya. National Center for Global Health and Medicine; Japón
Author affiliation: Flichman, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina
Author affiliation: Tokunaga, Katsushi. University of Tokyo; Japón
Author affiliation: Mizokami, Masashi. National Center for Global Health and Medicine; Japón
Repository: CONICET Digital (CONICET). Consejo Nacional de Investigaciones Científicas y Técnicas