Authors: Costa Carvalho, Beatriz Tavares; Sevciovic Grumach, Anete; Franco, José Luis; Espinosa Rosales, Francisco Javier; Leiva, Lily E.; King, Alejandra; Porras, Oscar; Bezrodnik, Liliana; Oleastro, Mathias; Sorensen, Ricardo U.; Condino Neto, Antonio
Publication Date: 2013.
Purpose: Patients with primary immunodeficiency diseases (PIDD) may present with recurrent infections affecting different organs, organ-specific inflammation/autoimmunity, and also increased cancer risk, particularly hematopoietic malignancies. The diversity of PIDD and the wide age range over which these clinical occurrences become apparent often make the identification of patients difficult for physicians other than immunologists. The aim of this report is to develop a tool for educative programs targeted to specialists and applied by clinical immunologists. Methods: Considering the data from national surveys and clinical reports of experiences with specific PIDD patients, an evidence-based list of symptoms, signs, and corresponding laboratory tests were elaborated to help physicians other than immunologists look for PIDD. Results: Tables including main clinical manifestations, restricted immunological evaluation, and possible related diagnosis were organized for general practitioners and 5 specialties. Tables include information on specific warning signs of PIDD for pulmonologists, gastroenterologists, dermatologists, hematologists, and infectious disease specialists. Conclusions: This report provides clinical immunologists with an instrument they can use to introduce specialists in other areas of medicine to the warning signs of PIDD and increase early diagnosis. Educational programs should be developed attending the needs of each specialty.
Author affiliation: Costa Carvalho, Beatriz Tavares. Universidade Federal de São Paulo; Brasil
Author affiliation: Sevciovic Grumach, Anete. Fundação ABC. Faculdade de Medicina; Brasil
Author affiliation: Franco, José Luis. Universidad de Antioquia; Colombia
Author affiliation: Espinosa Rosales, Francisco Javier. Instituto Nacional de Pediatría. Unidad de Investigación en Inmunodeficiencias; México
Author affiliation: Leiva, Lily E.. State University of Louisiana; Estados Unidos
Author affiliation: King, Alejandra. Hospital de Niños Doctor Luis Calvo Mackenna. Unidad de Inmunología; Chile
Author affiliation: Porras, Oscar. Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera”; Costa Rica
Author affiliation: Bezrodnik, Liliana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Author affiliation: Oleastro, Mathias. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Author affiliation: Sorensen, Ricardo U.. State University of Louisiana; Estados Unidos. Universidad de La Frontera. Facultad de Medicina; México
Author affiliation: Condino Neto, Antonio. Universidade de Sao Paulo; Brasil
Repository: CONICET Digital (CONICET). Consejo Nacional de Investigaciones Científicas y Técnicas