Abstract:
The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Polygonum ferrugineum Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both Trypanosoma cruzi (IC50 = 9.5 μM, IC50 = 34.7 μM benznidazol, Y strain) epimastigotes and Trypanosoma brucei (IC50 = 4.8 μM, IC50 = 6.4 μM pentamidine, 29-13 strain) procyclic forms, which was also corroborated on T. brucei strain 427 (IC50 = 6.2 μM). In order to learn more about its properties, unspecific cytotoxicity on Hep G2 cells was investigated as well as the trans-splicing inhibitory potential on T. brucei cells. The results shown here point to flavokawin B as a candidate in the search for new agents. It is also cheaper and less toxic than the available drugs to treat trypanosomiasis with a special focus on sleeping sickness disease.
Author affiliation: Rodrigues, Danilo F.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Author affiliation: Maniscalco, David A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Author affiliation: Silva, Flavia A. J.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Author affiliation: Chiari, Bruna G.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Author affiliation: Castelli, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Author affiliation: Isaac, Vera L. B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Author affiliation: Cicarelli, Regina M. B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Author affiliation: López, Silvia Noelí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina