Authors: Hirschler, V.; Martin, Maximiliano Emanuel; Oestreicher, K.; Molinari, C.; Tetzlaff, Walter Francisco; Botta, Eliana Elizabeth; Boero, Laura Estela; Brites, Fernando Daniel
Publication Date: 2018.
Language: English.
Abstract:
Background: Children living at high altitude in San Antonio de los Cobres (SAC), Argentina, were shown to have lower high-density lipoprotein cholesterol (HDL-C) levels than Buenos Aires (BA) children. HDL antioxidant capacity is mainly attributed to paraoxonase1 (PON1). Objective: To compare PON1 activity in indigenous SAC vs. BA children. Methods: A cross-sectional study compared 158 SAC vs. 97 BA children (6–16 years). Anthropometric data and lipoprotein profile were measured. PON1 was evaluated employing paraoxon (PON) and phenylacetate (ARE) activity. Results: The prevalence of overweight/obesity was lower in SAC than in BA children (18.3 vs. 30.9%). Triglycerides (1.34 vs. 0.90 mmol/l), apo B (0.84 vs.0.72 g/l), apo A-I (1.33 vs. 1.27 g/l), and ARE activity (100 vs. 90 µmol/ml/min) were higher, while HDL-C (1.16 vs. 1.32 mmol/l) and PON activity (170 vs. 203 nmol/ml/min) were lower in SAC than in BA. Separate multiple linear regression analyses showed that SAC children had significantly higher triglyceride (Beta −0.38), apo B (Beta −0.34), and ARE (Beta −0.36) plus lower HDL-C (Beta 0.33) and PON (Beta 0.25) compared with BA; adjusted for age, gender, and BMI. Conclusion: SAC showed an unfavorable lipoprotein profile, lower PON and higher ARE activities compared with BA children, suggesting the presence of altered HDL metabolism and antioxidant capacity.
Author affiliation: Hirschler, V.. Universidad de Buenos Aires; Argentina
Author affiliation: Martin, Maximiliano Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Oestreicher, K.. Universidad de Buenos Aires; Argentina
Author affiliation: Molinari, C.. Universidad de Buenos Aires; Argentina
Author affiliation: Tetzlaff, Walter Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Botta, Eliana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Boero, Laura Estela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Brites, Fernando Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Repository: CONICET Digital (CONICET). Consejo Nacional de Investigaciones Científicas y Técnicas
Authors: Gomez Rosso, Leonardo Adrián; Lhomme, Marie; Meroño, Tomás; Sorroche, Patricia Beatriz; Catoggio, Luis; Soriano, Enrique; Saucedo, Carla; Malah, Verónica; Dauteuille, Carolane; Boero, Laura Estela; Lesnik, Philippe; Robillard, Paul; Chapman, M. John; Brites, Fernando Daniel; Kontush, Anatol
Publication Date: 2014.
Language: English.
Abstract:
OBJECTIVE: High-density lipoprotein (HDL) particles exert potent antiatherogenic activities, including antioxidative actions, which are relevant to attenuation of atherosclerosis progression. Such activities are enriched in small, dense HDL and can be compromised under conditions of chronic inflammation like rheumatoid arthritis (RA). However, structure-function relationships of HDL largely remain indeterminate. METHODS: The relationships between HDL structure and function were evaluated in normolipidemic patients with active RA (DAS28 > 3.2; n = 12) and in normolipidemic age-matched controls (n = 10). Small, dense HDL3b and 3c particles were isolated from plasma or serum by density gradient ultracentrifugation and their physicochemical characteristics, lipidome (by LC/MS/MS) and antioxidative function (as protection of normolipidemic LDL from free radical-induced oxidation) were evaluated. RESULTS: As expected, active RA patients featured significantly elevated plasma levels of high-sensitivity C-reactive protein (hsCRP; p < 0.001) and serum amyloid A (SAA; p < 0.01) relative to controls. Antioxidative activity and weight % chemical composition of small, dense HDL did not differ between RA patients and controls (p > 0.05), whereas HDL phosphosphingolipidome was significantly altered in RA. Subgroup analyses revealed that RA patients featuring high levels of inflammation (hsCRP>10 mg/l) possessed small, dense HDL with reduced antioxidative activities (p < 0.01). Furthermore, antioxidative activity of HDL was inversely correlated with plasma hsCRP (p < 0.01). CONCLUSIONS: These data revealed that (i) despite normolipidemic state, the lipidome of small, dense HDL was altered in RA and (ii) high levels of inflammation can be responsible for the functional deficiency of small, dense HDL in RA.
Author affiliation: Gomez Rosso, Leonardo Adrián. Inserm; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Author affiliation: Lhomme, Marie. Inserm; Francia. Universite Pierre et Marie Curie; Francia
Author affiliation: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Author affiliation: Sorroche, Patricia Beatriz. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina
Author affiliation: Catoggio, Luis. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina
Author affiliation: Soriano, Enrique. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina
Author affiliation: Saucedo, Carla. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina
Author affiliation: Malah, Verónica. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Author affiliation: Dauteuille, Carolane. Inserm; Francia. Universite Pierre et Marie Curie; Francia
Author affiliation: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Author affiliation: Lesnik, Philippe. Inserm; Francia. Universite Pierre et Marie Curie; Francia
Author affiliation: Robillard, Paul. Inserm; Francia. Universite Pierre et Marie Curie; Francia
Author affiliation: Chapman, M. John. Inserm; Francia. Universite Pierre et Marie Curie; Francia
Author affiliation: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Author affiliation: Kontush, Anatol. Inserm; Francia. Universite Pierre et Marie Curie; Francia
Repository: CONICET Digital (CONICET). Consejo Nacional de Investigaciones Científicas y Técnicas
Authors: Menafra, Martín; Meroño, Tomás; Matoso, María Dolores; Boero, Laura Estela; Gomez Rosso, Leonardo Adrián; Saez, María Soledad; Sorroche, Patricia Beatriz; de Paula, P.; Brites, Fernando Daniel
Publication Date: 2013.
Language: Spanish.
Abstract:
En pacientes con enfermedad celíaca (EC), se ha observado mayor incidencia de eventos cardiovasculares que en controles, sin la presencia de factores de riesgo aterogénico clásicos. El objetivo de este estudio fue evaluar los factores de riesgo nóveles y biomarcadores de inflamación y enfermedad cardiovascular en pacientes con EC, con presentación típica y atípica. Fueron seleccionados 14 pacientes con EC sin tratamiento y controles pareados por sexo y edad. Se determinaron parámetros hematológicos, indicadores del metabolismo de los hidratos de carbono, proteína C reactiva ultrasensible (PCRus), per- fil lipoproteico y actividades de proteína transportadora de colesterol esterificado (CETP) y fosfolipasa A2 asociada a lipoproteínas (Lp-PLA2). Los pacientes con EC presentaron niveles plasmáticos mayores de insulina (7,2 mU/l vs. 4,4 mU/l; p<0,05) y mayor índice HOMA-IR (1,45 vs. 0,98; p<0,05) que los controles. Por otro lado, se observó menor concentración de colesterol-HDL (50 vs. 62 mg/dl; p<0,05), mayor cociente triglicéridos/colesterol-HDL y niveles de PCRus más altos (4,56 vs. 1,17 mg/l; p<0,05) en los pacientes que en los controles. Al comparar a los pacientes con presentación típica (n=8) y atí- pica (n=6), aquellos con presentación típica mostraron menores niveles de apo A-I (128 vs. 178 mg/dl; p<0,01) y aumento del cociente apo B/apo A-I (0,72 vs. 0,43; p<0,05), así como mayor actividad de LpPLA2 (7,9 umol/ml.h vs. 6,15 umol/ml.h; p<0,05). La interacción de las alteraciones descriptas durante períodos de tiempo prolongados en una condición patológica crónica como la EC constituirían un mayor riesgo de desarrollo de enfermedad cardiovascular aterosclerótica.
In patients with celiac disease (CD), it has been reported higher incidence of cardiovascular events than in controls, without the presence of classical atherogenic risk factors. The aim of this study was to evaluate the novel risk factors and biomarkers of inflammation and cardiovascular disease in patients with CD, with typical and atypical presentation. We selected 14 patients with CD without treatment and 14 healthy sex and age-matched controls. Haematological parameters, indicators of carbohydrates metabolism, high sensitive C reactive protein (hsCRP), lipoprotein profile and the activities of cholesteryl ester transfer protein (CETP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) were determined. CD patients presented higher insulin plasma levels (7.2 mU/l vs. 4.4 mU/l, p <0.05) and increased HOMA-IR index (1.45 vs. 0.98, p <0.05) than controls. On the other hand, lower HDLcholesterol concentration (50 vs. 62 mg/dl, p<0.05), higher TG/HDL-cholesterol ratio and increased hsCRP levels (4.56 vs. 1.17 mg / l, P <0.05) were observed in comparison with control subjects. When comparing patients with typical (n=8) and atypical (n=6) presentation, the former showed lower apo A-I levels (128 vs. 178 mg/dl, p<0.01), and higher apo B/apo A-I ratio (0.72 vs. 0.43, p<0.05) and LpPLA2 activity (7.9 umol/ml.h vs. 6.15 umol/ml.h, p<0.05). The interaction among the alterations above described during long periods of time in a chronic pathological condition such as CD could constitute higher risk of development of atherosclerotic cardiovascular disease.
Author affiliation: Menafra, Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Author affiliation: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Author affiliation: Matoso, María Dolores. Hospital Italiano; Argentina
Author affiliation: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Author affiliation: Gomez Rosso, Leonardo Adrián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Author affiliation: Saez, María Soledad. Hospital Italiano; Argentina
Author affiliation: Sorroche, Patricia Beatriz. Hospital Italiano; Argentina
Author affiliation: de Paula, P.. Hospital Italiano; Argentina
Author affiliation: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Repository: CONICET Digital (CONICET). Consejo Nacional de Investigaciones Científicas y Técnicas
Authors: Boero, Laura Estela; Meroño, Tomás; Manavela, M.; Danilowicz, K.; Maidana, P.; Buttazzoni, M.; Menafra, M.; Gomez Rosso, Leonardo Adrián; Brites, Fernando Daniel
Publication Date: 2012.
Language: Spanish.
Abstract:
El síndrome de Cushing constituye una condición patológica caracterizada por una elevación persistente e inapropiada de los niveles circulantes de glucocorticoides y cuya tasa de mortalidad resulta 4 veces mayor que la esperada en la población general. Los eventos cardiovasculares son, en su mayoría, los responsables de la elevada morbi-mortalidad de los pacientes afectados. El objetivo del estudio fue caracterizar las alteraciones del metabolismo de los hidratos de carbono y de los lípidos, y evaluar la presencia de factores de riesgo aterogénico emergentes y biomarcadores de aterosclerosis en pacientes con síndrome de Cushing activo. Se estudiaron 32 pacientes con síndrome de Cushing activo (23 mujeres) y 32 controles pareados por sexo y edad [34 (27 - 42) vs. 33 (27 - 45) años, pacientes y controles, respectivamente]. Fueron evaluados parámetros antropométricos, niveles plasmáticos de cortisol, marcadores de resistencia insulínica, incluidas las adipocitoquinas adiponectina y resistina, perfil lipoproteico, actividades de enzimas y proteínas asociadas a lipoproteínas, niveles de lipoproteínas de baja densidad oxidadas y de proteína C reactiva ultrasensible, y recuento de leucocitos. El grupo de pacientes con síndrome de Cushing presentó características típicas de la patología como sobrepeso, obesidad central e hipercortisolismo (28 ± 12 vs. 12 ± 5 μg/dl, p < 0.0001, respectivamente). Los pacientes también exhibieron un estado de resistencia insulínica, con elevación de la concentración de resistina [(16 (10 - 22) vs. 6 (5 - 9) ng/ml, p < 0.0001, respectivamente)], un perfil lipoproteico más aterogénico, aumento de los niveles de lipoproteínas de baja densidad oxidadas (100 ± 31 vs. 75 ± 32 U/l, p < 0.05, respectivamente) y un estado proinflamatorio caracterizado por aumento de la concentración de proteína C reactiva ultrasensible [1,2 (0,6 - 3,1) vs. 0,6 (0,3 - 1,1) mg/l, p < 0,05] y mayor recuento de leucocitos (9,5 ± 2,6 vs. 6,5 ± 1,4.103 células/μl, p < 0,0001). En conclusión, la conjunción de las alteraciones metabólicas y la presencia de factores de riesgo y biomarcadores de inflamación y aterosclerosis en los pacientes con síndrome de Cushing activo condicionan un mayor riesgo de enfermedad cardiovascular.
Cushing syndrome constitutes a pathological condition characterised by a continuous and inappropriate elevation of circulating glucocorticoids and whose mortality is 4 times higher than in general population. Cardiovascular events are mostly responsible for the elevated morbidity and mortality of affected patients. The aim of the present study was to characterise the alterations in carbohydrate and lípid metabolism, and to evaluate the presence of novel atherogenic risk factors and biomarkers on atherosclerosis in patients with active Cushing syndrome. We studied 32 patients with active Cushing syndrome (23 women) y 32 sex and age-matched controls [34 (27 - 42) vs. 33 (27 - 45) years, patients and controls, respectively]. The following evaluations were carried out: anthropometric parameters, cortisol plasma levels, markers of insulin resistance, including the adipocytokines adiponectin and resistin, lipoprotein profile, activities of lipoprotein-associated enzymes and proteins, oxidized low density lipoprotein and high sensitive C reactive protein levels, and leukocyte count. The group of patients with Cushing syndrome presented typical characteristics of the pathology such as overweight, central obesity and hypercortisolism. (28 ± 12 vs. 12 ± 5 μg/dl, p < 0.0001, respectively). Patients also exhibited an insulin resistant state, with high resistin levels [(16 (10 - 22) vs. 6 (5 - 9) ng/ml, p < 0.0001, respectively)], a more atherogenic lipoprotein profile, high oxidized low density lipoprotein levels (100 ± 31 vs. 75 ± 32 U/l, p < 0.05, respectively) and a proinflammatory state characterised by increased high sensitive C reactive protein levels [1.2 (0.6 – 3.1) vs. 0.6 (0.3 – 1.1) mg/l, p < 0.05] and higher leukocyte count (9.5 ± 2.6 vs. 6.5 ± 1.4.103 cells/ μl, p < 0.0001). In conclusion, the combination of the metabolic alterations observed and the presence of risk factors and biomarkers of inflammation and atherosclerosis in patients with active Cushing syndrome determine an increased risk of cardiovascular disease.
Author affiliation: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Author affiliation: Manavela, M.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Author affiliation: Danilowicz, K.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Author affiliation: Maidana, P.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Buttazzoni, M.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Author affiliation: Menafra, M.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Gomez Rosso, Leonardo Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Repository: CONICET Digital (CONICET). Consejo Nacional de Investigaciones Científicas y Técnicas
Authors: Boero, Laura Estela; Manavela, M.; Meroño, Tomás; Maidana, P.; Gomez Rosso, Leonardo Adrián; Brites, Fernando Daniel
Publication Date: 2012.
Language: English.
Abstract:
CONTEXT: Acromegaly is characterized by GH excess and insulin resistance. It is not known which of these disorders is responsible for the increased atherogenic risk in these patients. OBJECTIVE: To analyse the associations of GH and homoeostasis model assessment (HOMA) with biomarkers of cardiovascular disease and to compare the above-mentioned variables between patients with active acromegaly and controls. DESIGN AND SETTING: This open cross-sectional study was conducted at a University Hospital. PATIENTS: Twenty-two outpatients were compared with sex- and age-matched control subjects. MAIN OUTCOMES: Included clinical features, hormonal status, markers of insulin resistance, lipoprotein profile and biomarkers of cardiovascular disease. RESULTS: Patients presented higher triglyceride (median [IQR]) (1·2[1·1-1·6] vs 0·9[0·6-1·1] mm, P < 0·05), low-density lipoprotein-cholesterol (LDL-C) (mean ± SD) (3·5 ± 0·9 vs 3·0 ± 0·7mm, P < 0·05), apoB (0·98 ± 0·23 vs 0·77 ± 0·22 g/l, P < 0·05), free fatty acid (0·69 ± 0·2 vs 0·54 ± 0·2 mM, P < 0·05), oxidized-LDL (120 ± 22 vs 85 ± 19 U/l, P < 0·05) and endothelin-1 (0·90 ± 0·23 vs 0·72 ± 0·17 ng/l, P < 0·05) levels, increased cholesteryl ester transfer protein (CETP) activity (179 ± 27 vs 138 ± 30%/ml/h, P < 0·01) and lower C reactive protein (CRP) (0·25[0·1-0·9] vs 0·85[0·4-1·4] mg/l; P < 0·05) levels than control subjects. Vascular cell adhesion molecule (VCAM-1) concentration was not different. By multiple linear regression analyses, HOMA explained the variability of triglycerides (25%), high-density lipoprotein-cholesterol (HDL-C) (30%) and CETP activity (28%), while GH independently predicted LDL-C (18%), oxidized-LDL (40%) and endothelin-1 levels (19%). CONCLUSIONS: In patients with active acromegaly, GH excess contributes to the development of insulin resistance, and the interaction between both disturbances would be responsible for the appearance of atherogenic pro-oxidative and pro-inflammatory factors. Insulin resistance would be preferably associated with an atherogenic lipoprotein profile and to high CETP activity, while high GH levels would independently predict the increase in LDL-C, ox-LDL and endothelin-1.
Author affiliation: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Author affiliation: Manavela, M.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas Gral. San Martín. División Endocrinologia; Argentina
Author affiliation: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Author affiliation: Maidana, P.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Gomez Rosso, Leonardo Adrián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Author affiliation: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Repository: CONICET Digital (CONICET). Consejo Nacional de Investigaciones Científicas y Técnicas
Authors: Tetzlaff, Walter Francisco; Meroño, Tomás; Menafra, Martín; Martin, Maximiliano; Botta, Eliana Elizabeth; Matoso, María Dolores; Sorroche, Patricia Beatriz; De Paula, Juan A; Boero, Laura Estela; Brites, Fernando Daniel
Publication Date: 2017.
Language: English.
Abstract:
AIM: To evaluate novel risk factors and biomarkers of cardiovascular disease in celiac disease (CD) patients compared with healthy controls.METHODS:Twenty adult patients with recent diagnosis of CD and 20 sex, age and body mass index-matched healthy controls were recruited during a period of 12 mo.Indicators of carbohydrate metabolism, hematological parameters and high sensitive C reactive protein were determined. Moreover, lipoprotein metabolism was also explored through evaluation of the lipid profile and the activity of cholesteryl ester transfer protein and lipoprotein associated phospholipase A2, which is also considered a specific marker of vascular inflammation. The protocol was approved by the Ethic Committee from School of Pharmacy and Biochemistry, University of Buenos Aires and from Buenos Aires Italian Hospital, Buenos Aires, Argentina.RESULTS: Regarding the indicators of insulin resistance, CD patients showed higher plasma insulin levels [7.2 (5.0-11.3) mU/L vs 4.6 (2.6-6.7) mU/L, P < 0.05], increased Homeostasis Model Assessment-Insulin Resistance [1.45 (1.04-2.24) vs 1.00 (0.51-1.45), P < 0.05] and lower Quantitative Sensitive Check index [0.33 (0.28-0.40) vs 0.42 (0.34-0.65), P < 0.05] indexes. Folic acid concentration [5.4 (4.4-7.9) ng/mL vs 12.2 (8.0-14.2) ng/mL, P < 0.01] resulted to be lower and High-sensitivity C reactive protein levels higher (4.21 ± 6.47 mg/L vs 0.98 ± 1.13 mg/L, P < 0.01) in the patient group. With respect to the lipoprotein profile, CD patients showed lower high density lipoproteincholesterol (HDL-C) (45 ± 15 mg/dL vs 57 ± 17 mg/dL, P < 0.05) and apo A-I (130 ± 31 mg/dL vs 155 ± 29 mg/ dL, P < 0.05) levels, as well as higher total cholesterol/ HDL-C [4.19 (3.11-5.00) vs 3.52 (2.84-4.08), P < 0.05] and apo B/apo A-I (0.75 ± 0.25 vs 0.55 ± 0.16, P < 0.05) ratios in comparison with control subjects. No statistically significant differences were detectedin lipoprotein-associated lipid transfer protein and enzymes.CONCLUSION: The presence and interaction of the detected alterations in patients with CD, would constitute a risk factor for the development of atherosclerotic cardiovascular disease.
Author affiliation: Tetzlaff, Walter Francisco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Meroño, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Menafra, Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Martin, Maximiliano. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Botta, Eliana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Matoso, María Dolores. Hospital Italiano; Argentina
Author affiliation: Sorroche, Patricia Beatriz. Hospital Italiano; Argentina
Author affiliation: De Paula, Juan A. Hospital Italiano; Argentina
Author affiliation: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Author affiliation: Brites, Fernando Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Repository: CONICET Digital (CONICET). Consejo Nacional de Investigaciones Científicas y Técnicas